Nicotinamide adenine dinucleotide (NAD+) is a foundational cellular coenzyme that participates in redox reactions and is a required substrate for the sirtuin family of NAD+-dependent deacetylases and for poly(ADP-ribose) polymerases (PARPs) in DNA repair. Cellular NAD+ concentrations decline with age, which underpins research interest in NAD+ replenishment strategies.
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Last reviewed 22 July 2026.