For Research Purposes Only · Not For Human Consumption

Batch-Matched CoA Available
Research Use Only · Not For Human Consumption
Same-Day Dispatch from Manchester
Independently Tested · Accredited External Lab
Stored at −20°C Until Dispatch
Home/Buy/MOTS-C 10mg
MOTS-C 10mg vial
CoA verified

Mitochondrial / Metabolic Research

MOTS-C 10mg

MOTS-c peptide — 16 amino acids, encoded in the mitochondrial genome. Studied for AMPK activation, insulin sensitivity and metabolic homeostasis.

Vial size

Quantity

£24.99

In stock

Inc. VAT · Add £25.01 more for free UK shipping

How many
1
Order before 6pm Monday for same-day dispatch

SSL encrypted · CoA published for this lot

Delivery.
£3.99 Tracked 24, free over £50. Same-day dispatch before 6pm. Details
Payment.
Bank transfer, approved in your banking app. We never see your card or bank details.
Returns.
14 days if unopened. Damaged or wrong items replaced free. Policy
Verification.
Independently HPLC-tested. Signed CoA for this lot is on this page.

Certificate of Analysis

MOTS-C 10mg

Independent lab
an accredited independent laboratory
Batch number
UKP-MOTS-2608
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — MOTS-C 10mgView full Certificate of Analysis for batch UKP-MOTS-2608 →

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Sealed vial
-20°C, protect from light
Once reconstituted
Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution.
Diluent
Bacteriostatic water (0.9% benzyl alcohol)
Shipping
Insulated, ice packs
+ Add Bacteriostatic Water (£1.99) →
FAQ

MOTS-C 10mg — common questions

6 more questions
Research Compound

About MOTS-C

MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino-acid peptide encoded within the mitochondrial genome. First characterised by Cohen et al. (2015), MOTS-C acts as an AMPK activator and is one of the most researched mitochondrial-derived peptides in metabolic pathway biology. ≥98% HPLC, batch-matched CoA.

Research areas

  • AMPK activation
  • Insulin sensitivity
  • Mitochondrial biogenesis
  • Glucose homeostasis
  • Exercise mimetic models
Compound Profile

MOTS-C 10mg — mechanism, research applications & compound data

MOTS-C peptide — written MOTS-c in the literature, and MOT-C, MOTC or MOTSC by some suppliers — is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA region of the mitochondrial genome, first characterised by Cohen et al. (2015). Research has established MOTS-c as an AMPK activator with documented effects on insulin sensitivity, glucose homeostasis and mitochondrial biogenesis — earning it the label 'exercise mimetic' in the metabolic literature.

UK Peptides supplies MOTS-C 10mg as ≥98% HPLC lyophilised powder with a signed third-party CoA.

Read the full MOTS-C technical profile (6 sections) →
01

MOTS-C peptide benefits reported in the research literature

"MOTS-c benefits" is one of the most common searches around this compound, so it is worth being exact about what has actually been shown. Every finding below comes from cell culture or rodent work — no human clinical trial of MOTS-c has been completed:

  • AMPK activation and increased glucose disposal in skeletal muscle (Lee et al., Cell Metabolism 2015)
  • Reduced diet-induced obesity and improved insulin sensitivity in high-fat-fed mice
  • Increased mitochondrial biogenesis via PGC-1α upregulation
  • Exercise-induced expression, with effects on age-dependent physical decline in mice (Reynolds et al., Nature Communications 2021)
  • Nuclear translocation under metabolic stress, regulating antioxidant and metabolic gene expression (Kim et al., Cell Metabolism 2018)
02

MOTS-C side effects: what is and is not known

There is no side-effect profile for MOTS-c, because no published human clinical trial has been completed. Rodent studies have not reported overt toxicity at the quantities used, but that is an absence of reported findings across a handful of animal studies — not a safety result.

Endogenous MOTS-c does circulate in human plasma and declines with age, which is sometimes offered as reassurance; it is not one. An endogenous peptide being tolerated at physiological concentrations says nothing about administered quantities. Any source describing MOTS-c as free of side effects is describing a gap in the data rather than a finding.

03

MOTS-C research applications

The 10mg vial supports extended research protocols. Published research covers:

  • Insulin sensitivity and diabetes models
  • Obesity and metabolic syndrome research
  • Exercise-mimetic pathway studies
  • Mitochondrial biogenesis and PGC-1α signalling
  • Cellular stress and longevity research
  • Comparison alongside Humanin and SHLP peptides
04

Storage and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze after reconstitution.

05

≥98% HPLC purity

Every MOTS-C 10mg vial is independently HPLC-UV tested to ≥98% purity by an accredited independent laboratory, with identity confirmed against a reference standard. The signed PDF CoA is supplied with every order.

06

Buying MOTS-C peptide in the UK

MOTS-C peptide UK stock is held in Manchester and dispatched the same working day on orders placed before 6pm GMT. MOTS-c UK delivery is Royal Mail Tracked 24 in insulated cold-chain packaging. Every batch is third-party HPLC verified before it is listed, and the signed CoA for the exact lot in your vial is downloadable from this page — not a generic sample document.

Buying MOTS-c from UK stock also avoids the customs delays and uncontrolled thermal exposure that come with international shipments of a lyophilised peptide.

The science, in depth

Mechanism, the published evidence and handling detail for MOTS-C are covered in full in our research library — 6 referenced articles rather than a summary on a product page.

References & further reading

Primary sources cited on this page

MOTS-c is a 16-residue peptide encoded within the 12S ribosomal RNA region of the mitochondrial genome — one of a small family of mitochondrial-derived peptides (MDPs) characterised by Cohen and colleagues. Research has established MOTS-c as an AMP-activated protein kinase (AMPK) activator in cell and animal models.

Sources & related pages

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

Last reviewed 22 July 2026.

Research Library

Further reading on MOTS-C

Peer-referenced articles from our research library covering mechanism, evidence and handling.

Related

Researchers also ordered

View all →

Every batch independently tested by an accredited independent laboratory before dispatch. The signed certificate for this lot is published on this page.

Third-party HPLC-UV testing Lot-matched CoA on every order Batch-traceable from dispatch

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.

MOTS-C 10mg

£24.99