Thymalin

Thymalin in the research literature

Almost everything published on Thymalin comes from one source, the St Petersburg Institute of Bioregulation and Gerontology, where Khavinson and Morozov first prepared the extract. Anisimov and Khavinson, 2010, review the group's own long-term rodent studies and clinical observations. Khavinson and colleagues, 2020, cultured human haematopoietic stem cells with Thymalin and followed expression of the surface markers CD44, CD117 and CD28. Linkova and colleagues, 2023, is the paper that treats the dipeptides Lys-Glu and Glu-Trp as the active substances: it docks each against double-stranded DNA, runs promoter and pathway bioinformatics, and measures IL-1β, IL-6 and TNF-α by ELISA in lipopolysaccharide-stimulated blood mononuclear cells from four donors.

Two cautions. No independent English-language critical review of Thymalin exists on PubMed. And the studies above use the Russian drug, a calf thymus extract, so their findings do not transfer directly to a synthetic single dipeptide sold under the same name.

Thymalin: what is actually in the vial

The Russian medicine Thymalin is a polypeptide extract of calf thymus, CAS 79621-14-0, with no single structure, formula or mass and no PubChem compound record. Research vials labelled Thymalin usually hold something narrower: the synthetic dipeptide Glu-Trp, also called thymogen, CID 100094, 333.3 Da, one of the two dipeptides the Khavinson group names as the drug's active substances. A few vendors instead describe a bovine-derived complex. The lab report, once published on this page, will settle which this is: a single dipeptide gives one mass at 333.3 Da, while an extract shows a spread of peptides. It is not thymulin, a nine-residue peptide. To buy Thymalin UK there is one 10mg size, with packs of two, three or five at 10, 20 and 30% off. Same-day dispatch from Manchester, free UK delivery over £40.