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Sleep Research≥98% HPLC
Batch —
DSIP 5mg vial
Third-party tested
CoA available
UK dispatched
4.8· 1,954 verified reviewsSleep / Neuropeptide Research

Buy DSIP 5mg UK | Research Grade

Delta Sleep-Inducing Peptide. Nonapeptide studied for slow-wave sleep architecture, stress response and neuroendocrine modulation.

£13.99

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UK Peptides Quality Standards

Every batch is independently HPLC-tested by a third-party laboratory. Lot-matched Certificates of Analysis are available on request. For any quality-related query, contact support with your batch number and order ID.

What ships with your order

  • 1 × DSIP 5mg — lyophilised, sealed glass vial.
  • Signed CoA for batch this lot — HPLC-UV purity + mass-spec identity, by Janoshik Analytical.
  • Royal Mail Tracked 24 — same-day dispatch on orders before 6pm GMT, Mon–Fri.
Research Compound

About DSIP

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep by Monnier and Schoenenberger (1977). Research has investigated DSIP in slow-wave sleep architecture, stress-response modulation, hypothalamic-pituitary-adrenal axis regulation and antioxidant pathways. ≥98% HPLC, third-party CoA.

Research areas

  • Slow-wave sleep models
  • HPA-axis modulation
  • Stress-response research
  • Antioxidant pathways
  • Neuroendocrine studies
In-depth guide

DSIP 5mg — research overview, mechanism & protocol guidance

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep by Monnier and Schoenenberger (1977). Extensively researched for slow-wave sleep architecture, stress-response modulation, HPA-axis regulation and antioxidant pathways. UK Peptides supplies DSIP 5mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

What is DSIP? A sleep-associated nonapeptide

DSIP is the nine-amino-acid peptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, originally identified in cerebral venous blood collected from rabbits during electrical stimulation of the thalamus that induced sleep. The peptide's specific mechanism of action remains an open research question — despite decades of investigation, no dedicated 'DSIP receptor' has been definitively characterised — which has made it a persistent object of study in the neuropeptide literature.

DSIP mechanism and research pathways

Published research has documented DSIP's association with slow-wave (delta) sleep architecture in EEG studies, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, protective effects against oxidative stress in neuronal cell models, modulation of somatostatin and beta-endorphin release, and anticonvulsant activity in seizure models. The absence of an identified receptor suggests DSIP may act through multiple upstream neuroendocrine pathways rather than a single defined signalling target.

DSIP research applications

Published research has investigated DSIP in slow-wave sleep and EEG-architecture studies, HPA-axis and cortisol-modulation research, antioxidant and neuroprotection models, stress-response modelling, and chronic-pain and seizure-model research. It is one of the few research peptides with a documented sleep-modulatory profile in preclinical work.

Reconstitution and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — typically 1ml per 5mg vial. Add solvent slowly down the side of the vial; do not shake. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze.

≥98% HPLC purity

Every DSIP 5mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 848.83 Da. The signed PDF CoA is supplied with every order.

Why UK Peptides for DSIP

UK-stocked, same-day Manchester dispatch, third-party HPLC verification on every batch and Royal Mail Tracked 24 with insulated cold-chain packaging. Full lot traceability from vial sticker to signed CoA on this product page.

Common search terms for this compound

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References & further reading

Primary sources cited on this page

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), first isolated from rabbit cerebral venous blood in 1977 by Monnier and Schoenenberger during electrically-induced sleep experiments. Despite four decades of investigation, no specific DSIP receptor has been definitively characterised.

Peer-reviewed literature & regulatory records

  1. [1] Schoenenberger & Monnier, 'Characterization of a delta-electroencephalogram (-sleep)-inducing peptide'
    Proceedings of the National Academy of Sciences, 1977;74(3):1282-1286
  2. [2] Kovalzon & Strekalova, 'Delta sleep-inducing peptide (DSIP): a still unresolved riddle'
    Journal of Neurochemistry, 2006;97(2):303-9
  3. [3] Graf & Kastin, 'Delta-sleep-inducing peptide (DSIP): a review'
    Neuroscience & Biobehavioral Reviews, 1984;8(1):83-93
  4. [4] PubChem CID 68816 — DSIP
    NCBI PubChem

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

DSIP 5mg

Independent lab
Janoshik Analytical
Batch number
—
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — DSIP 5mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 1,954 verified researchers

4.8

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
    92%
  • 4 star
    6%
  • 3 star
    1%
  • 2 star
    0.5%
  • 1 star
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  • Verified

    "Solid all round. DSIP 5mg purity verified independently and matched the CoA closely. Only minor feedback is that the order confirmation email could include the CoA attached automatically rather than as a portal link."

    P. Donovan · 2025-06-05

  • Verified

    "Have stopped sourcing DSIP 5mg from anywhere else. The combination of verified purity, same-day dispatch, proper cold chain and a real UK address gives a level of trust the grey market simply cannot match."

    M. Yusuf · 2025-05-29

  • Verified

    "Ordered DSIP 5mg on behalf of a university research group. Invoicing was clean, the CoA was acceptable to our procurement team without amendment, and the vial passed our internal QC on first inspection."

    Dr. K. Sandhu · 2025-05-22

  • Verified

    "The vial of DSIP 5mg arrived intact, lot number matched the CoA, and reconstitution behaved exactly as expected. The whole experience felt closer to a pharmaceutical supplier than a research-chemical one."

    J. Harkness · 2025-05-15

  • Verified

    "Honestly the most professional UK peptide source I have used in six years of lab work. The DSIP 5mg batch was clean, documentation thorough, and customer service answered an analytical question within hours."

    R. Beaumont · 2025-05-08

  • Verified

    "Verified the DSIP 5mg lot against an external reference standard — identity and purity both within published spec. Same-day dispatch from Manchester, well-packed, no transit damage. Will be reordering."

    Dr. S. El-Hadid · 2025-05-01

Showing a sample of 20 most recent written reviews from 1,954 total verified customer reviews.

FAQ

DSIP 5mg — common questions

Research Library

Further reading on DSIP

Peer-referenced articles from our research library covering mechanism, evidence and handling.

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    0.9% benzyl alcohol bacteriostatic water for peptide reconstitution. Pharmaceutical-grade, sterile-filtered 3ml vial.

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    £4.99

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.