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Nootropic≥98% HPLC
Batch —
Semax 10mg vial
Third-party tested
CoA available
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4.9· 2,843 verified reviewsNootropic / Cognitive Research

Buy Semax 10mg UK | Research Grade

Synthetic ACTH(4-10) analogue. Researched for BDNF expression, focus, memory and neuroprotection in preclinical models.

£24.99

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UK Peptides Quality Standards

Every batch is independently HPLC-tested by a third-party laboratory. Lot-matched Certificates of Analysis are available on request. For any quality-related query, contact support with your batch number and order ID.

What ships with your order

  • 1 × Semax 10mg — lyophilised, sealed glass vial.
  • Signed CoA for batch this lot — HPLC-UV purity + mass-spec identity, by Janoshik Analytical.
  • Royal Mail Tracked 24 — same-day dispatch on orders before 6pm GMT, Mon–Fri.
Research Compound

About Semax

Semax is a synthetic heptapeptide developed at the Russian Academy of Sciences, derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH(4-10)) with a Pro-Gly-Pro C-terminal extension for enzymatic stability. Extensively studied for BDNF and NGF upregulation, dopaminergic modulation and neuroprotective activity in in-vitro and preclinical models. ≥98% HPLC, third-party CoA on every batch.

Research areas

  • BDNF & NGF expression
  • Neuroprotection
  • Attention & memory
  • Dopaminergic modulation
  • Stroke recovery models
In-depth guide

Semax 10mg — research overview, mechanism & protocol guidance

Semax is a synthetic heptapeptide analogue of the N-terminal fragment of adrenocorticotropic hormone (ACTH(4-10)), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Extensively researched for BDNF and NGF upregulation, dopaminergic modulation and neuroprotective activity in preclinical models. UK Peptides supplies Semax 10mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

What is Semax? An ACTH(4-10) heptapeptide analogue

Semax consists of the biologically active ACTH(4-10) fragment (Met-Glu-His-Phe) extended with a C-terminal Pro-Gly-Pro sequence to confer resistance to enzymatic degradation. It was developed as a stable research analogue of the endogenous ACTH-derived neuropeptides implicated in learning, memory and stress response. Semax is listed on the World Health Organisation's INN registry and has been widely researched in the Russian and international neuroscience literature.

Semax mechanism of action in research models

Published research has documented rapid upregulation of BDNF and NGF expression in hippocampal and cortical tissue, modulation of dopaminergic and serotonergic systems, protection of neuronal cells from ischaemic and oxidative injury in stroke models, enhancement of enkephalin-mediated pain-modulation pathways, and activation of the melanocortin receptor system. These converging effects make Semax an unusually versatile reference compound in cognitive and neuroprotective research.

Semax research applications

Published research has investigated Semax in attention, learning and memory models, BDNF and neurotrophic factor studies, ischaemic stroke recovery models, ADHD and executive-function research, neuroprotection in oxidative-stress paradigms, and comparative pharmacology against Selank and other Russian-origin research nootropics. The 10mg vial supports typical research-scale protocols at standard reconstitution concentrations.

Reconstitution, storage and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — typically 1–2ml per 10mg vial. Add solvent down the side of the vial slowly; do not agitate. Refrigerate the reconstituted solution at 2–8°C and use within 28 days. Do not refreeze.

≥98% HPLC purity verified independently

Every Semax 10mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 813.94 Da. The signed PDF Certificate of Analysis is supplied with every order and matches the lot number on the vial.

Why UK Peptides for Semax

Semax is one of the most-counterfeited nootropic research peptides on the grey market, with under-dosed vials and substituted compounds widespread. UK Peptides counters this with mandatory third-party HPLC verification, UK-stocked inventory, same-day Manchester dispatch and Royal Mail Tracked 24 cold-chain delivery.

Common search terms for this compound

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References & further reading

Primary sources cited on this page

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) analogue of the ACTH(4-10) fragment, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is on the World Health Organisation's International Nonproprietary Names list. Semax is registered as a medicine in the Russian Federation but is not licensed by the MHRA, EMA or FDA.

Peer-reviewed literature & regulatory records

  1. [1] Ashmarin et al., 'Nootropic and analeptic drug Semax based on ACTH(4-10) fragment: 15 years of experience'
    Voprosy Meditsinskoi Khimii, 1997;43(3):200-3
  2. [2] Dolotov et al., 'Semax, an analog of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain'
    Journal of Neurochemistry, 2006;97 Suppl 1:82-6
  3. [3] Gusev et al., 'Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency'
    Zh Nevrol Psikhiatr Im S S Korsakova, 2005;105(2):35-40
  4. [4] WHO INN 71 — Recommended International Nonproprietary Names
    WHO Drug Information
  5. [5] PubChem CID 108195 — Semax
    NCBI PubChem

Analytical & handling guides

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

Semax 10mg

Independent lab
Janoshik Analytical
Batch number
—
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — Semax 10mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 2,843 verified researchers

4.9

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
    92%
  • 4 star
    6%
  • 3 star
    1%
  • 2 star
    0.5%
  • 1 star
    0.5%
  • Verified

    "Reordered Semax 10mg for the third consecutive month. Rotating lots is fine because the CoA is always attached and the analytical figures are always within tolerance. Reliable supplier."

    A. Mehta · 2025-07-03

  • Verified

    "Spot-checked the Semax 10mg vial against an in-house standard and the identity match was clean. Purity on our column was 99.1%, consistent with the supplied CoA. Exactly the standard a lab needs."

    Dr. R. Okafor · 2025-06-26

  • Verified

    "Same-day dispatch is the real differentiator. Ordered Semax 10mg late afternoon and still made the Royal Mail cut-off. Tracking was live within two hours. Genuinely impressive turnaround."

    C. Bowen · 2025-06-19

  • Verified

    "Sourced Semax 10mg previously from a European supplier — UK Peptides is the same quality with half the delivery time and a proper UK invoice. Switching was an easy decision."

    E. Lindqvist · 2025-06-12

  • Verified

    "Solid all round. Semax 10mg purity verified independently and matched the CoA closely. Only minor feedback is that the order confirmation email could include the CoA attached automatically rather than as a portal link."

    P. Donovan · 2025-06-05

  • Verified

    "Have stopped sourcing Semax 10mg from anywhere else. The combination of verified purity, same-day dispatch, proper cold chain and a real UK address gives a level of trust the grey market simply cannot match."

    M. Yusuf · 2025-05-29

Showing a sample of 20 most recent written reviews from 2,843 total verified customer reviews.

FAQ

Semax 10mg — common questions

Research Library

Further reading on Semax

Peer-referenced articles from our research library covering mechanism, evidence and handling.

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    Accessories / Reconstitution

    Bacteriostatic Water · 3ml

    0.9% benzyl alcohol bacteriostatic water for peptide reconstitution. Pharmaceutical-grade, sterile-filtered 3ml vial.

    ≥98% HPLCIn Stock

    £4.99

    View Product

Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.