PEG-MGF

PEG-MGF in the research literature

The literature on PEG-MGF itself is thin. The papers cited on this page study the unmodified E peptide or peptide detection in general; none takes a PEGylated MGF as its subject, and no peer-reviewed standard for PEG size or attachment point exists. What the conjugate inherits is the MGF literature. Yang and Goldspink, 2002, compared the IGF-1Ec E peptide with mature IGF-1 in myoblast culture, and Matheny and colleagues, 2010, kept the word putative in their review title, since no receptor for the E peptide had been identified.

PEGylation is a chemistry choice, not a biological finding: a polyethylene glycol chain is bonded covalently to the peptide to add mass and slow clearance in laboratory models. PEG is a polymer with a range of chain lengths, so the product has no exact formula, mass or CAS number. Thevis and colleagues, 2014, reviewed how mass spectrometry handles peptidic drugs and analogues in sports doping work, where PEG-MGF is most often analysed.

PEG-MGF vs MGF: which to order

PEG-MGF is the choice when the model needs a slower-clearing form of the E peptide; MGF is the choice when identity and mass need to be exact. The 2mg on a PEG-MGF label is the mass of conjugate, PEG included, so peptide content is lower than in a 2mg MGF vial and depends on the chain length used. Chain length and attachment point are not standardised, so masses from different suppliers cannot be compared. The lab report, once published on this page, will show a mass distribution for the conjugate rather than one peak, with the peptide core at 2,868.2 Da. Check either label for the R23H variant. One size; packs of two, three and five take 10, 20 and 30% off. Buy PEG-MGF UK from us: same-day dispatch from Manchester, free UK delivery over £40.