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Longevity≥98% HPLC
Batch —
NAD+ 500mg vial
Third-party tested
CoA available
UK dispatched
4.9· 3,421 verified reviewsLongevity / Metabolic Research

Buy NAD+ 500mg UK | Research Grade

Nicotinamide Adenine Dinucleotide. Central coenzyme in cellular energy metabolism, sirtuin activity and DNA repair research.

£49.99

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UK Peptides Quality Standards

Every batch is independently HPLC-tested by a third-party laboratory. Lot-matched Certificates of Analysis are available on request. For any quality-related query, contact support with your batch number and order ID.

What ships with your order

  • 1 × NAD+ 500mg — lyophilised, sealed glass vial.
  • Signed CoA for batch this lot — HPLC-UV purity + mass-spec identity, by Janoshik Analytical.
  • Royal Mail Tracked 24 — same-day dispatch on orders before 6pm GMT, Mon–Fri.
Research Compound

About NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a foundational coenzyme present in every living cell, central to redox reactions, sirtuin-mediated deacetylation, PARP-driven DNA repair and mitochondrial energy metabolism. NAD+ levels decline with age, driving intense research interest in NAD+ replenishment as a longevity and cellular-repair model. Supplied as ≥98% HPLC lyophilised powder with third-party CoA.

Research areas

  • Sirtuin activation (SIRT1/SIRT3)
  • PARP-mediated DNA repair
  • Mitochondrial redox
  • Cellular senescence
  • Longevity pathway modelling
In-depth guide

NAD+ 500mg — research overview, mechanism & protocol guidance

NAD+ (Nicotinamide Adenine Dinucleotide) is a foundational coenzyme central to redox metabolism, sirtuin-mediated deacetylation and PARP-driven DNA repair in every living cell. Cellular NAD+ levels decline with age, driving intense research interest in NAD+ replenishment as a longevity and cellular-repair model. UK Peptides supplies NAD+ 500mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

What is NAD+? A foundational cellular coenzyme

NAD+ is a dinucleotide composed of nicotinamide and adenine linked by phosphate groups. It cycles between oxidised (NAD+) and reduced (NADH) forms as it accepts and donates electrons in cellular metabolism. Beyond redox chemistry, NAD+ is a required substrate for the sirtuin family of NAD+-dependent deacetylases, poly(ADP-ribose) polymerases (PARPs) involved in DNA repair, and CD38/CD157 ectoenzymes. Its central position across metabolism and repair biology makes it one of the most-studied cellular molecules in longevity research.

NAD+ mechanism and research pathways

Sirtuin activity — particularly SIRT1 and SIRT3 — depends directly on cellular NAD+ availability. As NAD+ declines with age, sirtuin-mediated deacetylation of histone and non-histone substrates falls, contributing to the transcriptional and metabolic dysregulation observed in ageing tissue. Simultaneously, PARP hyperactivation under DNA damage consumes NAD+ pools, further depleting the substrate available for sirtuin and mitochondrial function. NAD+ replenishment research examines whether restoring cellular NAD+ pools reverses these downstream effects.

NAD+ research applications

Published research has investigated NAD+ and its precursors (NR, NMN) in sirtuin activity and gene-silencing models, mitochondrial function and PGC-1α expression, DNA-repair capacity via PARP activity, cellular senescence and telomere research, longevity pathway pharmacology, and metabolic health models. The 500mg vial supports extended in-vitro and cell-culture research protocols.

Reconstitution, storage and handling

Store the lyophilised NAD+ powder at -20°C, sealed and protected from light. NAD+ is moderately hygroscopic — allow the vial to reach room temperature before opening. Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Refrigerate the reconstituted solution at 2–8°C and use within 28 days. NAD+ oxidises on prolonged exposure to air, so keep the vial sealed between draws.

≥98% HPLC purity verified

Every NAD+ 500mg lot is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of 663.43 Da. The signed PDF Certificate of Analysis is supplied with every order.

Why UK Peptides for NAD+

UK stock, same-day Manchester dispatch, third-party HPLC verification on every batch and Royal Mail Tracked 24 delivery with insulated cold-chain packaging. Bundle with bacteriostatic water in a single insulated mailer to consolidate shipping.

Common search terms for this compound

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References & further reading

Primary sources cited on this page

Nicotinamide adenine dinucleotide (NAD+) is a foundational cellular coenzyme that participates in redox reactions and is a required substrate for the sirtuin family of NAD+-dependent deacetylases and for poly(ADP-ribose) polymerases (PARPs) in DNA repair. Cellular NAD+ concentrations decline with age, which underpins research interest in NAD+ replenishment strategies.

Peer-reviewed literature & regulatory records

  1. [1] Verdin E., 'NAD+ in aging, metabolism, and neurodegeneration'
    Science, 2015;350(6265):1208-1213
  2. [2] Rajman, Chwalek & Sinclair, 'Therapeutic potential of NAD-boosting molecules: the in vivo evidence'
    Cell Metabolism, 2018;27(3):529-547
  3. [3] Yoshino, Baur & Imai, 'NAD+ intermediates: the biology and therapeutic potential of NMN and NR'
    Cell Metabolism, 2018;27(3):513-528
  4. [4] Bogan & Brenner, 'Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition'
    Annual Review of Nutrition, 2008;28:115-130
  5. [5] PubChem CID 5892 — NAD+
    NCBI PubChem

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

NAD+ 500mg

Independent lab
Janoshik Analytical
Batch number
—
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — NAD+ 500mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 3,421 verified researchers

4.9

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
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  • 3 star
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  • Verified

    "Ordering process is straightforward, dispatch confirmation arrived within an hour, NAD+ 500mg vial was on my bench by 10am the next day. Packaging was discreet, professional, and properly insulated."

    S. Whitfield · 2025-07-10

  • Verified

    "Reordered NAD+ 500mg for the third consecutive month. Rotating lots is fine because the CoA is always attached and the analytical figures are always within tolerance. Reliable supplier."

    A. Mehta · 2025-07-03

  • Verified

    "Spot-checked the NAD+ 500mg vial against an in-house standard and the identity match was clean. Purity on our column was 99.1%, consistent with the supplied CoA. Exactly the standard a lab needs."

    Dr. R. Okafor · 2025-06-26

  • Verified

    "Same-day dispatch is the real differentiator. Ordered NAD+ 500mg late afternoon and still made the Royal Mail cut-off. Tracking was live within two hours. Genuinely impressive turnaround."

    C. Bowen · 2025-06-19

  • Verified

    "Sourced NAD+ 500mg previously from a European supplier — UK Peptides is the same quality with half the delivery time and a proper UK invoice. Switching was an easy decision."

    E. Lindqvist · 2025-06-12

  • Verified

    "Solid all round. NAD+ 500mg purity verified independently and matched the CoA closely. Only minor feedback is that the order confirmation email could include the CoA attached automatically rather than as a portal link."

    P. Donovan · 2025-06-05

Showing a sample of 20 most recent written reviews from 3,421 total verified customer reviews.

FAQ

NAD+ 500mg — common questions

Research Library

Further reading on NAD+

Peer-referenced articles from our research library covering mechanism, evidence and handling.

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.