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IGF-1 LR3 1mg vial
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4.9· 3,287 verified reviewsGrowth Factor Research

Buy IGF-1 LR3 1mg UK | Research Grade

Long R3 Insulin-like Growth Factor 1. Extended half-life IGF-1 analogue researched for myogenesis, hypertrophy and IGF-1R signalling.

£37.99

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UK Peptides Quality Standards

Every batch is independently HPLC-tested by a third-party laboratory. Lot-matched Certificates of Analysis are available on request. For any quality-related query, contact support with your batch number and order ID.

What ships with your order

  • 1 × IGF-1 LR3 1mg — lyophilised, sealed glass vial.
  • Signed CoA for batch this lot — HPLC-UV purity + mass-spec identity, by Janoshik Analytical.
  • Royal Mail Tracked 24 — same-day dispatch on orders before 6pm GMT, Mon–Fri.
Research Compound

About IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is an 83-amino-acid recombinant analogue of human IGF-1, engineered with an N-terminal 13-amino-acid extension and an Arg³ substitution that reduces IGFBP binding, dramatically extending plasma half-life. Extensively used as a reference IGF-1R agonist in myogenesis, hypertrophy and cellular proliferation research. ≥98% HPLC, third-party CoA.

Research areas

  • IGF-1R signalling
  • Myogenesis & hypertrophy
  • PI3K/Akt/mTOR pathway
  • Cellular proliferation
  • Muscle-cell differentiation
In-depth guide

IGF-1 LR3 1mg — research overview, mechanism & protocol guidance

IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is an 83-amino-acid recombinant analogue of human IGF-1, engineered with an N-terminal 13-amino-acid extension and an arginine-for-glutamate substitution at position 3 that dramatically reduces IGFBP binding and extends plasma half-life. It is the standard reference IGF-1R agonist in myogenesis and hypertrophy research. UK Peptides supplies IGF-1 LR3 1mg as ≥98% HPLC lyophilised powder with a signed third-party Certificate of Analysis.

What is IGF-1 LR3? An extended-half-life IGF-1 analogue

Native human IGF-1 is a 70-amino-acid single-chain protein that circulates largely bound to IGF-binding proteins (IGFBPs), which regulate its bioavailability. IGF-1 LR3 modifies this profile by adding a 13-amino-acid MFPAMPLSSLFVN extension to the N-terminus and substituting arginine for glutamate at position 3 — the two changes together produce an analogue with dramatically reduced IGFBP affinity and correspondingly higher free-fraction bioactivity per unit dose in in-vitro research models.

IGF-1 LR3 mechanism of action

IGF-1 LR3 binds the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase, triggering autophosphorylation and activation of the PI3K/Akt/mTOR and Ras/MAPK downstream signalling cascades. In muscle cell models, this drives myoblast proliferation, differentiation and hypertrophic protein synthesis. In hepatocyte research, it modulates gluconeogenesis and metabolic gene expression. Its reduced IGFBP binding means it acts on IGF-1R with less regulatory buffering than native IGF-1 in the same experimental system.

IGF-1 LR3 research applications

Published research has investigated IGF-1 LR3 in myogenesis and satellite-cell activation, muscle hypertrophy and protein-synthesis research, PI3K/Akt/mTOR signalling studies, comparative pharmacology against native IGF-1 and MGF (mechano growth factor), pancreatic beta-cell research, and cell-line proliferation assays. The 1mg vial supports typical research-scale in-vitro protocols; higher payloads are unusual because IGF-1 LR3 is highly potent per unit mass.

Reconstitution and stability

Store the lyophilised vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — some research protocols use acidified diluents (dilute acetic acid) to maximise long-term stability of IGF-1 analogues; either is acceptable at research scale. Refrigerate the reconstituted solution at 2–8°C and use within 14 days. For longer storage, aliquot and freeze at -20°C.

≥98% HPLC purity

Every IGF-1 LR3 1mg vial is independently HPLC-UV tested to ≥98% purity by Janoshik Analytical or Aspen Bioanalytics, with mass-spectrometry identity confirmation against the published molecular weight of approximately 9,111 Da. The signed PDF Certificate of Analysis is supplied with every order and matches the vial lot number.

Why UK Peptides for IGF-1 LR3

Recombinant growth-factor analogues are particularly sensitive to transit temperature — a vial that has warmed above 4°C for extended periods may show degradation before it reaches the bench. UK Peptides stocks IGF-1 LR3 in temperature-controlled storage, dispatches same-day in insulated cold-chain mailers and provides third-party HPLC verification on every batch.

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References & further reading

Primary sources cited on this page

IGF-1 LR3 (Long R3 IGF-1) is an 83-residue recombinant analogue of human insulin-like growth factor-1, with an N-terminal 13-residue extension and an arginine-for-glutamate substitution at position 3. Both modifications dramatically reduce affinity for IGF-binding proteins (IGFBPs), producing higher free-fraction bioactivity at the IGF-1 receptor in in-vitro systems than native IGF-1.

Peer-reviewed literature & regulatory records

  1. [1] Francis et al., 'Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency'
    Journal of Molecular Endocrinology, 1992;8(3):213-223
  2. [2] Tomas et al., 'Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats'
    Biochemical Journal, 1992;282(Pt 1):91-97
  3. [3] Adams TE., 'Structure and function of the type 1 insulin-like growth factor receptor'
    Cellular and Molecular Life Sciences, 2000;57(7):1050-1093
  4. [4] UniProt P05019 — Insulin-like growth factor I (human)
    UniProt Knowledgebase

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

IGF-1 LR3 1mg

Independent lab
Janoshik Analytical
Batch number
—
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — IGF-1 LR3 1mg

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: After reconstitution, store at 2–8°C and use within 14 days. Do not refreeze. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 3,287 verified researchers

4.9

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
    92%
  • 4 star
    6%
  • 3 star
    1%
  • 2 star
    0.5%
  • 1 star
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  • Verified

    "Quality control here clearly exceeds the average UK research-grade supplier. Reconstitution of the IGF-1 LR3 1mg powder was clean, no haze, dissolved properly in BAC water within seconds."

    Dr. C. Walsh · 2025-09-11

  • Verified

    "Ordered IGF-1 LR3 1mg on a Friday morning, arrived Saturday before midday — genuinely impressive logistics for a small UK operation. Vial was sealed, intact, and properly labelled."

    B. Atkinson · 2025-09-04

  • Verified

    "Switched to UK Peptides after two bad experiences with grey-market sources. The IGF-1 LR3 1mg I received was visibly cleaner powder, the documentation actually exists, and the price was lower. No going back."

    G. Peters · 2025-08-28

  • Verified

    "Cold chain on the IGF-1 LR3 1mg delivery was maintained the whole way — ice pack was still partially frozen when the parcel arrived in Edinburgh. Vial was undamaged. Will be the lab's default supplier going forward."

    T. Fairclough · 2025-08-21

  • Verified

    "Customer support replied to my pre-order question about the IGF-1 LR3 1mg batch within an hour with the actual CoA attached. That level of transparency is rare. Ordered the same evening."

    L. Grant · 2025-08-14

  • Verified

    "Ordered IGF-1 LR3 1mg together with bacteriostatic water and both arrived in the same insulated mailer the next day. Saves time, saves a second delivery, and the bundle pricing was fair."

    K. Patel · 2025-08-07

Showing a sample of 20 most recent written reviews from 3,287 total verified customer reviews.

FAQ

IGF-1 LR3 1mg — common questions

Research Library

Further reading on IGF-1 LR3

Peer-referenced articles from our research library covering mechanism, evidence and handling.

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.