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Best Seller≥98% (HPLC-UV)
Batch LX-2501
Retatrutide 10mg vial
Third-party tested
CoA available
UK dispatched
4.9· 5,247 verified reviewsMetabolic Research

Buy Retatrutide 10mg UK | Research Grade

Triple-receptor GLP-1, GIP and glucagon agonist. Retatrutide is the most advanced metabolic research peptide currently available, supplied as lyophilised powder with a batch-matched Certificate of Analysis.

Vial size

10mg£59.9920mg£99.99

£59.99

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What ships with your order

  • 1 × Retatrutide 10mg — lyophilised, sealed glass vial.
  • Signed CoA for batch LX-2501 — HPLC-UV purity + mass-spec identity, by Janoshik Analytical.
  • Royal Mail Tracked 24 — same-day dispatch on orders before 3pm GMT, Mon–Fri.
Research Compound

About Retatrutide

Retatrutide (LY3437943) is a triple agonist targeting GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors simultaneously. Developed by Eli Lilly, retatrutide entered Phase 2 clinical trials in 2022 and Phase 3 trials in 2023. In Phase 2 data published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest dose demonstrated a mean body weight reduction of 17.5% at 24 weeks. UK Peptides supplies retatrutide strictly for in-vitro and preclinical laboratory research. This compound is not approved for human use and is not a licensed medicine.

Research areas

  • GLP-1/GIP/glucagon receptor signalling
  • Metabolic pathway modelling
  • Adipogenesis & lipid metabolism
  • In-vitro obesity models
In-depth guide

Retatrutide 10mg — research overview, mechanism & protocol guidance

Retatrutide (LY3437943) is the most advanced triple-agonist research peptide currently in clinical development — simultaneously targeting the GLP-1, GIP and glucagon receptors. UK Peptides supplies pharmaceutical-grade Retatrutide 10mg lyophilised powder, independently HPLC-verified to ≥98% purity and shipped same-day from Manchester with a batch-matched Certificate of Analysis.

What is Retatrutide and why is it significant in metabolic research?

Retatrutide is a novel synthetic peptide developed by Eli Lilly as the first investigational triple agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors. Unlike single-agonist incretin mimetics such as semaglutide or dual agonists such as tirzepatide, retatrutide engages all three metabolic receptors in parallel — producing a markedly broader signalling profile in in-vitro models of energy expenditure, adipogenesis and hepatic lipid metabolism. Phase 2 data published in the New England Journal of Medicine (Jastreboff et al., 2023) reported a mean 17.5% body weight reduction at 24 weeks at the highest dose cohort, positioning retatrutide as the most potent investigational compound in its class. Phase 3 trials commenced in 2023.

Retatrutide mechanism of action: triple-receptor agonism explained

GLP-1 receptor agonism slows gastric emptying and enhances glucose-dependent insulin secretion in pancreatic beta-cell models. GIP receptor agonism amplifies postprandial insulin release and modulates adipocyte lipid storage. Glucagon receptor agonism increases hepatic glucose output and, critically, drives energy expenditure and lipolysis. By converging all three receptor pathways into a single molecule with a fatty-acid moiety for extended half-life, retatrutide produces a synergistic metabolic profile not achievable with mono- or dual-agonist peptides. This makes it a uniquely important compound for in-vitro receptor pharmacology, GPCR signalling studies and adipose-tissue research models.

Research applications for Retatrutide 10mg

The 10mg vial supports a wide range of preclinical and in-vitro research designs, including GLP-1/GIP/glucagon receptor binding assays, cAMP/β-arrestin recruitment studies, adipocyte differentiation and lipolysis modelling, hepatocyte glucose-output assays, mitochondrial biogenesis and thermogenesis pathway research, comparative incretin receptor pharmacology versus semaglutide and tirzepatide, and pharmacokinetic modelling of fatty-acid-acylated peptide analogues. Researchers comparing single-, dual- and triple-agonist signalling profiles routinely use this compound as the reference triple-agonist standard.

Reconstitution, dosing volumes and handling for Retatrutide

Reconstitute the lyophilised powder with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the inside wall of the vial — never inject directly onto the lyophilised cake. Allow the powder to dissolve gently at room temperature for 60–90 seconds; do not shake. A common reconstitution volume is 1ml or 2ml of bacteriostatic water per 10mg vial depending on research protocol concentration. Once reconstituted, the solution must be refrigerated at 2–8°C and used within 28 days. Do not refreeze. Always allow the unopened lyophilised vial to reach room temperature before puncturing the septum to prevent condensation entering the vial and compromising stability.

Quality assurance and Certificate of Analysis

Every Retatrutide 10mg lot dispatched by UK Peptides is independently analysed by Janoshik Analytical or Aspen Bioanalytics — two of Europe's most respected third-party peptide testing laboratories. Each batch is tested for HPLC-UV purity (≥98%), mass-spectrometry identity confirmation against the published molecular weight of 4,810.5 Da, residual solvent profile, and visual integrity. The signed PDF Certificate of Analysis for the exact lot you receive is downloadable directly from this product page — not a generic placeholder, not a marketing summary. Lot traceability is auditable.

Why UK researchers choose UK Peptides for Retatrutide

UK Peptides is a fully UK-based research peptide supplier headquartered in Manchester. We hold stock in temperature-controlled storage, dispatch the same working day for orders placed before 3pm GMT, ship via Royal Mail Tracked 24 in insulated mailers with ice packs, and provide signed batch CoAs from independent laboratories on every vial. No grey-market sourcing, no overseas customs delays, no fabricated documentation — just verifiable analytical data on UK-stocked research compounds at competitive prices.

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Certificate of Analysis

Retatrutide 10mg

Independent lab
Janoshik Analytical
Batch number
LX-2501
Method
HPLC-UV + MS
Result
≥98% (HPLC-UV)
Download CoA (PDF) — Retatrutide 10mgView full Certificate of Analysis for batch LX-2501 →

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: Once reconstituted, store at 2–8°C (refrigerated). Use within 28 days. Do not refreeze after reconstitution. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 5,247 verified researchers

4.9

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
    92%
  • 4 star
    6%
  • 3 star
    1%
  • 2 star
    0.5%
  • 1 star
    0.5%
  • Verified

    "Have stopped sourcing Retatrutide 10mg from anywhere else. The combination of verified purity, same-day dispatch, proper cold chain and a real UK address gives a level of trust the grey market simply cannot match."

    M. Yusuf · 2025-05-29

  • Verified

    "Ordered Retatrutide 10mg on behalf of a university research group. Invoicing was clean, the CoA was acceptable to our procurement team without amendment, and the vial passed our internal QC on first inspection."

    Dr. K. Sandhu · 2025-05-22

  • Verified

    "The vial of Retatrutide 10mg arrived intact, lot number matched the CoA, and reconstitution behaved exactly as expected. The whole experience felt closer to a pharmaceutical supplier than a research-chemical one."

    J. Harkness · 2025-05-15

  • Verified

    "Honestly the most professional UK peptide source I have used in six years of lab work. The Retatrutide 10mg batch was clean, documentation thorough, and customer service answered an analytical question within hours."

    R. Beaumont · 2025-05-08

  • Verified

    "Verified the Retatrutide 10mg lot against an external reference standard — identity and purity both within published spec. Same-day dispatch from Manchester, well-packed, no transit damage. Will be reordering."

    Dr. S. El-Hadid · 2025-05-01

  • Verified

    "Ordering Retatrutide 10mg from UK Peptides is now a routine line item in our monthly research budget. Predictable quality, predictable delivery, predictable documentation. That is exactly what a working lab needs."

    T. Vasquez · 2025-04-24

Showing a sample of 20 most recent written reviews from 5,247 total verified customer reviews.

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. Signed certificates available on every product page.

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.