For Research Purposes Only · Not For Human Consumption

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Recovery
TB-500 5mg vial
Third-party tested
CoA available
UK dispatched
4.9396 verified reviewsCoA verified

Recovery / Healing

Buy TB-500 5mg UK | Research Grade

Thymosin Beta-4 fragment analogue. Researched for tissue repair, inflammation and cardiovascular recovery.

£23.99

In stock

Inc. VAT · Add £26.01 more for free UK shipping

1
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SSL encrypted · CoA published for this lot

Delivery.
£3.99 Royal Mail Tracked 24, free over £50. Order before 6pm GMT on a working day and it ships the same day — most UK mainland addresses arrive the next working day. Delivery details
Payment.
UK bank transfer via Fena Open Banking — you approve it inside your own banking app. We never see or store your card or bank details.
If it's not right.
14 days to change your mind while the vial is unopened and sealed. Damaged, leaking or incorrect items are replaced or refunded at our cost. Returns policy
Verification.
Independently HPLC-tested. The signed, lot-matched CoA for this batch is published further down this page — read it before you buy.

About this lot

  • Lot UKPL-493 certificate — Signed HPLC-UV + mass-spec result for the exact lot you receive.
  • Tested by an independent lab — Janoshik Analytical or Aspen Bioanalytics — not tested in-house by us.
  • Held and dispatched in the UK — Manchester stock, Royal Mail Tracked 24, no overseas customs step.
  • Research use only — Unlicensed compound, not approved by the MHRA for human use.
How we verify what we publish →

What you receive

  • 011 × TB-500 5mg — lyophilised, sealed glass vial
  • 02Signed CoA by email — batch UKPL-493, HPLC-UV + mass-spec. Sent with your confirmation, not enclosed in the parcel.
  • 03Royal Mail Tracked 24 — same-day dispatch before 6pm, Mon–Fri
Research Compound

About TB-500

TB-500 is a synthetic analogue of the naturally occurring peptide Thymosin Beta-4. ≥98% HPLC, third-party CoA on every batch.

Research areas

  • Muscle repair
  • Inflammation
  • Cardiovascular tissue
  • Flexibility
  • Systemic recovery
Compound Profile

TB-500 5mg — mechanism, research applications & compound data

TB-500 is a synthetic analogue of the active fragment of Thymosin Beta-4 (TB4), one of the body's most abundant actin-binding regenerative peptides. UK Peptides supplies TB-500 5mg lyophilised powder at ≥98% HPLC-UV verified purity, with a signed third-party Certificate of Analysis on every batch, dispatched same-day from Manchester via Royal Mail Tracked 24.

01

What is TB-500? Thymosin Beta-4 fragment analogue

TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, a 43-amino-acid naturally occurring peptide present in nearly all human tissues and the highest-concentration G-actin sequestering molecule in mammalian cells. Synthetic TB-500 reproduces the biologically active fragment responsible for actin regulation, cell migration and angiogenesis observed in TB4 research, while being significantly more soluble and easier to handle in laboratory settings.

02

TB-500 mechanism of action in preclinical research

Research has linked TB-500 to the pathways below. Its small size relative to native TB4 also gives it favourable distribution properties in tissue-penetration research.

  • G-actin sequestration and cytoskeletal reorganisation
  • Increased migration of fibroblasts, keratinocytes and endothelial cells
  • Inflammation modulation via NF-κB suppression
  • Angiogenesis through VEGF and Tie-2 pathways
  • Tissue repair in cardiac, dermal and musculoskeletal models
03

TB-500 research applications

Published research has investigated TB-500 in wound-healing models, cardiac ischaemia and post-infarction repair studies, corneal regeneration, tendon and ligament recovery, neuroprotection in stroke models, hair follicle migration studies, and inflammation modulation in autoimmune research models. It is widely used alongside BPC-157 in comparative recovery-peptide research because the two compounds act through different but complementary regenerative pathways.

04

Reconstitution, storage and stability for TB-500

Store the lyophilised TB-500 vial at -20°C, sealed and protected from light. Reconstitute with bacteriostatic water (0.9% benzyl alcohol) — a typical starting volume is 2ml per 5mg vial. Add solvent down the inside wall of the vial gently; do not agitate. Once reconstituted, refrigerate at 2–8°C and use within 28 days. Do not refreeze after reconstitution.

05

≥98% HPLC purity verified by independent laboratories

Every TB-500 5mg vial is independently tested by Janoshik Analytical or Aspen Bioanalytics to ≥98% HPLC-UV purity with mass-spectrometry identity confirmation against the published molecular weight of approximately 4,963 Da. The signed PDF Certificate of Analysis is supplied with every order and matches the lot number printed on the vial.

06

Why UK Peptides for TB-500

UK Peptides is a UK-based research peptide supplier with same-day dispatch on orders before 6pm GMT, cold-chain insulated packaging, Royal Mail Tracked 24 delivery, and verifiable third-party batch CoAs available on request. Stocked in the UK, dispatched from Manchester, supported by a UK customer service team that replies within 4 working hours.

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References & further reading

Primary sources cited on this page

TB-500 is a synthetic peptide corresponding to a fragment of Thymosin Beta-4 (TMSB4X), a 43-residue actin-sequestering peptide first isolated from calf thymus in 1981 by Low, Hu and Goldstein. TB-500 is the C-terminal fragment most commonly studied in wound-healing and cardiac repair research.

Peer-reviewed literature & regulatory records

  1. [1] Low, Hu & Goldstein, 'Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity'
    Proceedings of the National Academy of Sciences, 1981;78(2):1162-1166
  2. [2] Goldstein et al., 'Thymosin β4: actin-sequestering protein moonlights to repair injured tissues'
    Trends in Molecular Medicine, 2005;11(9):421-429
  3. [3] Bock-Marquette et al., 'Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair'
    Nature, 2004;432:466-472
  4. [4] Malinda et al., 'Thymosin beta 4 accelerates wound healing'
    Journal of Investigative Dermatology, 1999;113(3):364-368
  5. [5] UniProt P62328 — Thymosin beta-4 (human)
    UniProt Knowledgebase

Regulatory & compliance notice

This product is supplied strictly for in-vitro laboratory research. It is not a licensed medicine in the United Kingdom, is not approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency for human or veterinary use, and is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page constitutes medical advice.

External links point to primary literature or regulatory records and open in a new tab. Citations are provided so the reader can independently verify every factual claim made on this page. Last reviewed 22 July 2026.

Certificate of Analysis

TB-500 5mg

Independent lab
Janoshik Analytical
Batch number
UKPL-493
Method
HPLC-UV + MS
Result
≥98% HPLC
Download CoA (PDF) — TB-500 5mgView full Certificate of Analysis for batch UKPL-493 →

The CoA you download is the exact certificate produced for this lot — no edits.

Storage & handling

Keep it stable, keep it sterile

Storage: Store lyophilised powder at -20°C in a sealed vial. Protect from light and moisture. Allow the vial to reach room temperature before opening to prevent condensation entering the vial. Do not store in a frost-free freezer. Reconstitution: Reconstitute using bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly down the side of the vial — do not shake. Allow to dissolve gently at room temperature. Reconstituted stability: After reconstitution, store at 2–8°C and use within 28 days. Shipping: All vials are dispatched in insulated mailers with ice packs to maintain cold chain during Royal Mail Tracked 24 transit.
+ Add Bacteriostatic Water (£4.99) →
Customer reviews

Trusted by 396 verified researchers

4.9

out of 5

Every review below comes from a confirmed UK Peptides customer who received and used this exact product. We do not edit, filter or remove low ratings.

  • 5 star
    92%
  • 4 star
    6%
  • 3 star
    1%
  • 2 star
    0.5%
  • 1 star
    0.5%
  • 4.0
    Verified

    "Solid all round. TB-500 5mg purity verified independently and matched the CoA closely. Only minor feedback is that the order confirmation email could include the CoA attached automatically rather than as a portal link."

    P. Donovan · 2025-06-05

  • 5.0
    Verified

    "Have stopped sourcing TB-500 5mg from anywhere else. The combination of verified purity, same-day dispatch, proper cold chain and a real UK address gives a level of trust the grey market simply cannot match."

    M. Yusuf · 2025-05-29

  • 5.0
    Verified

    "Ordered TB-500 5mg on behalf of a university research group. Invoicing was clean, the CoA was acceptable to our procurement team without amendment, and the vial passed our internal QC on first inspection."

    Dr. K. Sandhu · 2025-05-22

  • 5.0
    Verified

    "The vial of TB-500 5mg arrived intact, lot number matched the CoA, and reconstitution behaved exactly as expected. The whole experience felt closer to a pharmaceutical supplier than a research-chemical one."

    J. Harkness · 2025-05-15

  • 5.0
    Verified

    "Honestly the most professional UK peptide source I have used in six years of lab work. The TB-500 5mg batch was clean, documentation thorough, and customer service answered an analytical question within hours."

    R. Beaumont · 2025-05-08

  • 5.0
    Verified

    "Verified the TB-500 5mg lot against an external reference standard — identity and purity both within published spec. Same-day dispatch from Manchester, well-packed, no transit damage. Will be reordering."

    Dr. S. El-Hadid · 2025-05-01

Showing a sample of 20 most recent written reviews from 396 total verified customer reviews.

FAQ

TB-500 5mg — common questions

Research Library

Further reading on TB-500

Peer-referenced articles from our research library covering mechanism, evidence and handling.

Related

Researchers also ordered

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Every batch independently tested by Janoshik Analytical and Aspen Bioanalytics before dispatch. The signed certificate for this lot is published on this page.

Third-party HPLC-UV testing Lot-matched CoA on every order Batch-traceable from dispatch

Legal notice

This product is sold strictly for in-vitro laboratory research purposes only. It is not approved for human or veterinary use, is not a drug, food, or cosmetic, and should not be misused as such. UK Peptides accepts no liability for misuse. By purchasing you confirm you are a qualified researcher aged 18 or over.

TB-500 5mg

£23.99