The short answer
CJC refers to ConjuChem, the company that developed it. The 1295 is an internal series number carrying no chemical information. The name identifies a development programme, which is why it fails to distinguish the DAC and non-DAC forms.
Key facts
- CJC
- ConjuChem, the developer
- 1295
- Internal series number
- Chemical meaning of 1295
- None
- Covers
- Both DAC and non-DAC forms
- Masses covered
- 3647.2 and 3367.9 Da
- Ipamorelin code
- NNC 26-0161 (Novo Nordisk)
The company prefix
CJC is ConjuChem. Company-initial prefixes are a common development convention: NNC for Novo Nordisk (which is where ipamorelin's NNC 26-0161 comes from), LY for Eli Lilly, BI for Boehringer Ingelheim. The prefix identifies who made it, not what it is.
What the number does not mean
It is not a molecular weight, not a dose, not a residue count. CJC-1295 is 3647.2 Da with DAC and has 29 residues. As with TB-500's 500 and BPC-157's 157, the number is an internal designation, and reading chemistry into it is a recurring error across this whole field.
Research material referenced
CJC-1295 + Ipamorelin 5+5mg, third-party HPLC tested
Why the name is actively unhelpful here
This is worse than the usual case. Because CJC-1295 names a programme rather than a molecule, it covers both the DAC-conjugated peptide and the DAC-free one, two compounds differing by 279.3 Da and by two orders of magnitude in half-life. A name that cannot distinguish those is not merely uninformative; it actively obscures the most important difference.
What to use instead
CJC-1295 with DAC, or Modified GRF (1-29) for the DAC-free form. Better still, quote the molecular weight (3647.2 or 3367.9), which admits no ambiguity at all. Where a supplier says only CJC-1295, the mass on the certificate is the field that resolves it.
The pattern across this library
TB-500, BPC-157, CJC-1295 and DSIP are all development codes that outlived their programmes and became product names. Compounds that reach approval get generic names; compounds that do not keep their codes. The presence of a code as a product name is itself a small piece of information about where a compound got to.
Frequently asked questions
- What does CJC stand for?
- ConjuChem, the company that developed the compound.
- Does 1295 have chemical meaning?
- No. It is an internal series number. The molecular weight is 3647.2 Da with DAC and the peptide has 29 residues.
- Why is the name a problem?
- It names a programme, not a molecule, so it covers both the DAC and non-DAC forms: compounds differing by 279.3 Da and vastly in half-life.
Extended research context
The CJC-1295 & Ipamorelin deep dive
Deep dive: why CJC-1295 and Ipamorelin are studied together
CJC-1295 is a modified GHRH (growth-hormone-releasing hormone) analogue; Ipamorelin is a selective growth-hormone secretagogue that binds the ghrelin receptor (GHS-R1a). In pituitary-cell research models the two act on independent pathways whose downstream effect converges on GH release. CJC-1295 amplifies the endogenous GHRH signal while Ipamorelin adds a separate ghrelin-pathway stimulus. That's why supplier catalogues frequently package them together as a research reference blend.
DAC vs no-DAC: which CJC-1295 is which
'CJC-1295 with DAC' contains a Drug Affinity Complex (a Lys-maleimide moiety) that binds serum albumin and extends half-life to several days. 'CJC-1295 no-DAC' (also called Modified GRF 1-29) lacks the linker and clears in minutes. These are pharmacologically different peptides. A CoA must specify which form is in the vial; mass differs (~3,367 Da with DAC vs ~3,367 minus linker for no-DAC).
Ipamorelin's selectivity profile
Unlike earlier GHS-R agonists (e.g. GHRP-6), Ipamorelin was engineered for minimal cross-activity at cortisol- and prolactin-releasing pathways in research models. That receptor selectivity is why it is the reference secretagogue for controlled pituitary-cell studies.
Research applications
- ▸Pituitary-cell GH-release assays (comparator vs GHRH and hexarelin)
- ▸Half-life comparison studies: DAC vs no-DAC CJC-1295 forms
- ▸Ghrelin-receptor binding assays for Ipamorelin analogue development
- ▸Analytical HPLC method development for lipidated GHRH analogues
- ▸Stability testing under refrigerated storage
Handling checklist
- ✓Store lyophilised at −20 °C long-term
- ✓Reconstitute in bacteriostatic water; both peptides dissolve readily
- ✓Aliquot immediately, refrigerate at 2–8 °C, use within 28 days
- ✓Confirm salt form and DAC/no-DAC status on CoA before starting a study
- ✓Do not use for human administration (research reference only)
Common research-handling mistakes
Learnt from thousands of researcher orders across our UK labs.
✗ Confusing DAC and no-DAC CJC-1295
Fix: Check the CoA. The two have very different pharmacokinetics.
✗ Assuming Ipamorelin acts on GHRH receptors
Fix: It binds the ghrelin receptor (GHS-R1a), a separate pathway from CJC-1295.
✗ Storing reconstituted solution at room temperature
Fix: Refrigerate 2–8 °C after reconstitution.
Continue researching
Peer-reviewed guides, comparators and matched reference materials.
Related questions researchers ask
- Is CJC-1295 the same as Modified GRF 1-29?
- What is the difference between DAC and no-DAC CJC-1295?
- Does Ipamorelin raise cortisol?
- Why are CJC-1295 and Ipamorelin blended together?
- How long is the half-life of CJC-1295 with DAC?
Primary sources & clinical trials
Peer-reviewed research and registered trials from PubMed, ClinicalTrials.gov, PubChem, FDA and NIH. All links open in a new tab and point to the primary source, so every claim can be verified at origin.
- PubChemPubChem · CJC-1295 (CID 91971820)pubchem.ncbi.nlm.nih.gov
- PubChemPubChem · Ipamorelin (CID 9831659)pubchem.ncbi.nlm.nih.gov
- PubMedTeichman SL et al. J Clin Endocrinol Metab 2006 (PMID 16352683)pubmed.ncbi.nlm.nih.gov
- PubMedRaun et al., Ipamorelin, the first selective GH secretagogue. Eur J Endocrinol 1998 (PMID 9849822)pubmed.ncbi.nlm.nih.gov
- PubMedMüller TD et al., Ghrelin. Molecular Metabolism 2015 (PMID 26042199)pubmed.ncbi.nlm.nih.gov
- PubChemPubChem · CJC-1295 / mod GRF (1-29) (CID 56841945)pubchem.ncbi.nlm.nih.gov
- TrialClinicalTrials.gov · GH-secretagogue trialsclinicaltrials.gov
- GuidelineGoogle: Creating helpful, reliable, people-first contentdevelopers.google.com
Written and reviewed by
The UK Peptides Editorial Team · Research library, UK Peptides
The editorial team is responsible for supplier selection, batch release decisions and the content published in this research library. Every article here is sourced to primary literature and every product page to a signed third-party certificate. Corrections are made in place and the review date updated.
More CJC-1295 & Ipamorelin articles
- Ipamorelin Compared With the GHRPsAll three act at the ghrelin receptor. The difference Raun reported in 1998 was what ipamorelin did not do — raise cortisol and prolactin.
- Why These Two Are Studied TogetherTwo receptors, one output. The mechanistic rationale for pairing a GHRH analogue with a ghrelin receptor agonist — and what would be needed to test it.
- Synergy: A Word Worth Using CarefullyAdditive and synergistic are different claims with different evidential requirements. What would have to be shown, and what has been.
- The Teichman 2006 CJC-1295 StudyThe landmark pharmacokinetic study of CJC-1295 with DAC in healthy adults, published in JCEM in 2006 — and why it is sometimes miscited as Walker.
- What the Published Literature ContainsTwo human pharmacokinetic studies from 2006, a 1998 selectivity paper, and comparatively little else. A small but unusually clinical evidence base.
Popular across the research hub
One flagship guide from every other research category.
- Retatrutide ResearchRetatrutide Molecular Weight
- GHK-Cu (Copper Peptide)The 4,000 Genes Claim, Examined
- TB-500 (Thymosin β4 fragment)BPC-157 and TB-500 Together: What the Evidence Says
- BPC-157 (Pentadecapeptide)What Does BPC-157 Stand For?
- Peptide ReferenceAre Peptides Safe? It Depends Entirely on Which One
- Bacteriostatic WaterBacteriostatic Water for Reconstitution
- Research & Regulatory NewsHow NICE Decides Whether the NHS Funds a Medicine
- GLP-1 & Incretin ScienceWhat Happens to Bone When Load Comes Off
- MOTS-c (Mitochondrial Peptide)What Is MOTS-c? The Mitochondria-Encoded Peptide
- Semax (ACTH Fragment Peptide)What Is Semax? Origin, Sequence and Neurotrophin Mechanism
- Selank (Tuftsin Analogue)What Is Selank? Sequence, Origin and Enkephalin Mechanism
- DSIP (Delta Sleep-Inducing Peptide)DSIP Structure, Sequence and Physical Properties
- KLOW (Blend)KPV: The Component With a Different Parent
- GLOW (Blend)The Two Repair-Literature Components
- MT-2 (Melanotan II)Melanotan 2 Nasal Spray and Why the Dose Is Unknowable
- IGF-1 LR3Why LR3 Exists: The Cell Culture Application
- GlutathioneDoes Oral Glutathione Reach the Body?
- NAD+NAD+ and Ageing: What Is Actually Established
- KPVKPV Storage and Handling