The short answer
BPC-157 has a molecular weight of 1419.5 Da for the formula C62H98N16O22, corresponding to PubChem CID 9941957 and CAS 137525-51-0. The figure is consistent across sources because, unlike some research peptides, only one compound carries the name.
Key facts
- Molecular weight
- 1419.5 Da
- Formula
- C62H98N16O22
- Residues
- 15
- Average per residue
- ~94.6 Da
- PubChem CID
- 9941957
- Consistency
- Stable across sources
The figure and where it comes from
1419.5 Da is the molecular weight PubChem records for CID 9941957, the entry corresponding to CAS 137525-51-0. It is calculated from the molecular formula C62H98N16O22, which in turn follows from the sequence GEPPPGKPADDAGLV with the appropriate loss of water at each of the fourteen peptide bonds.
Why the average residue mass looks low
Dividing 1419.5 by fifteen gives roughly 94.6 Da per residue, which is below the typical average of about 110. That reflects composition: four prolines (97 Da), three glycines (57 Da, the smallest possible) and two alanines (71 Da) are all light residues, and there is no tryptophan, tyrosine or arginine to raise the average. A glycine- and proline-rich peptide is a light peptide.
Research material referenced
BPC-157 5mg, third-party HPLC tested
Why this figure does not drift
Because there is only one compound. TB-500's molecular weight is quoted anywhere between 889 and 4,963 Da depending on whether the source means the heptapeptide or the parent protein. GHK-Cu is quoted at 340 or 402 depending on whether copper is counted. BPC-157 has no such ambiguity: one name, one sequence, one mass.
Using it correctly
Molarity is peptide mass divided by 1419.5. The relevant caution is not the molecular weight but the peptide content: synthetic peptides are supplied as salts, so gross powder weight exceeds net peptide. A certificate stating peptide content separately is describing this properly, and using gross weight overstates the amount of compound present.
Verifying it
Mass spectrometry. 1419.5 is unambiguous, and the absence of cysteine and methionine means no disulfide or oxidation satellites should complicate the spectrum. A clean single species at the expected mass is the straightforward confirmation.
Frequently asked questions
- What is BPC-157's molecular weight?
- 1419.5 Da, for the formula C62H98N16O22, verified against PubChem CID 9941957.
- Why is the per-residue average so low?
- Composition. Four prolines, three glycines and two alanines are all light residues, and there is no tryptophan, tyrosine or arginine to raise it.
Extended research context
The BPC-157 (Pentadecapeptide) deep dive
Deep dive: the pentadecapeptide sequence
BPC-157 is a synthetic pentadecapeptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It is derived from a fragment identified in human gastric juice by the Zagreb research group (Sikirić and colleagues), whose body of published work spans three decades and covers models ranging from tendon repair to gut integrity. The 'BPC' initials stand for 'body protection compound', the group's original characterisation term.
Two forms: acetate salt vs arginate
BPC-157 is supplied most commonly as an acetate salt; a small subset of suppliers offer the arginate form, which has slightly different solubility and stability properties. For research reproducibility, keep the salt form consistent across a study and confirm which form the CoA specifies (mass ± counterion changes the reading).
Reading a BPC-157 CoA
A trustworthy BPC-157 CoA lists HPLC purity (target ≥98% area), mass-spec confirmation (~1,419 Da for the free peptide), water content (Karl Fischer), acetate content, and residual solvents. Some batches also include endotoxin data. Any missing category is a red flag for a compromised supply chain.
Research applications
- ▸Cell-culture models of gut epithelial integrity
- ▸Tendon fibroblast migration and collagen-synthesis assays
- ▸Angiogenesis models involving VEGF and NO signalling
- ▸Stability studies comparing acetate vs arginate salt forms
- ▸Analytical reference for pentadecapeptide HPLC methods
Handling checklist
- ✓Store lyophilised vial at −20 °C long-term (2–8 °C short-term)
- ✓Reconstitute with bacteriostatic water; a 5 mg vial dissolves cleanly
- ✓Aliquot reconstituted solution; keep refrigerated 2–8 °C, use within 28 days
- ✓Protect from light and repeated warming
- ✓Verify CoA: HPLC ≥98%, mass ~1,419 Da, salt form declared
Common research-handling mistakes
Learnt from thousands of researcher orders across our UK labs.
✗ Mixing acetate and arginate BPC-157 across a study
Fix: Choose one salt form and stay with it. Different masses and solubility.
✗ Assuming stability at room temperature
Fix: Refrigerate reconstituted solution; discard after 28 days.
✗ Buying without a CoA
Fix: Only source from suppliers that publish batch HPLC + mass-spec data.
Continue researching
Peer-reviewed guides, comparators and matched reference materials.
Related questions researchers ask
- What does BPC-157 stand for?
- Is BPC-157 the same as pentadecapeptide?
- Who discovered BPC-157?
- What is the difference between BPC-157 acetate and arginate?
- How is BPC-157 reconstituted for research?
Primary sources & clinical trials
Peer-reviewed research and registered trials from PubMed, ClinicalTrials.gov, PubChem, FDA and NIH. All links open in a new tab and point to the primary source, so every claim can be verified at origin.
- PubChemPubChem · BPC-157 (CID 9941957)pubchem.ncbi.nlm.nih.gov
- PubMedSikiric P et al., Stable gastric pentadecapeptide BPC 157. Curr Pharm Des 2011 (PMID 21548867)pubmed.ncbi.nlm.nih.gov
- PubMedSikiric P et al., Fistulas Healing: Stable Gastric Pentadecapeptide BPC 157 Therapy. Curr Pharm Des 2020 (PMID 32329684)pubmed.ncbi.nlm.nih.gov
- PubMedKrivic A et al., Achilles detachment in rat and stable gastric pentadecapeptide BPC 157. J Orthop Res 2006 (PMID 16583442)pubmed.ncbi.nlm.nih.gov
- PubMedCerovecki T et al., Pentadecapeptide BPC 157 improves ligament healing in the rat. J Orthop Res 2010 (PMID 20225319)pubmed.ncbi.nlm.nih.gov
- PubMedSeiwerth S et al., BPC 157 and blood vessels. Curr Pharm Des 2014 (PMID 23782145)pubmed.ncbi.nlm.nih.gov
- PubMedNIH PubMed: Complete BPC-157 literature (Sikiric group)pubmed.ncbi.nlm.nih.gov
- GuidelineGoogle: Creating helpful, reliable, people-first contentdevelopers.google.com
Written and reviewed by
The UK Peptides Editorial Team · Research library, UK Peptides
The editorial team is responsible for supplier selection, batch release decisions and the content published in this research library. Every article here is sourced to primary literature and every product page to a signed third-party certificate. Corrections are made in place and the review date updated.
More BPC-157 (Pentadecapeptide) articles
- BPC-157 vs TB-500 ComparedDifferent origins, sizes, mechanisms and evidential positions. BPC-157 has registered clinical trials; TB-500's literature largely concerns its parent protein.
- BPC-157 Structure and SequenceGEPPPGKPADDAGLV: fifteen residues, four prolines, three glycines, no cysteine or methionine and no aromatic residue. What that composition implies.
- The Proline Problem in BPC-157 SynthesisFour prolines, three consecutive, make solid-phase synthesis meaningfully harder. Why proline coupling is a recognised difficult step, and what it costs purity.
- BPC-157 Molecular Structure and Physical Properties1419.5 Da, net negatively charged, highly water-soluble, conformationally mixed. The physical consequences of a proline- and glycine-rich fifteen-mer.
- Pentadecapeptide: The Word and What It Tells YouPenta-deca-peptide is fifteen. Where BPC-157 sits on the spectrum from short peptide to protein, and why fifteen residues is a useful size.
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